As proteínas tau (ou proteínas τ) son proteínas asociadas aos microtúbulos que teñen a función de estabilizalos. Son abundantes nas neuronas do sistema nervioso central e son menos comúns noutros tecidos, pero tamén se expresan en niveis moi baixos nos astrocitos e oligodendrocitos do sistema nervioso central.

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  • As proteínas tau (ou proteínas τ) son proteínas asociadas aos microtúbulos que teñen a función de estabilizalos. Son abundantes nas neuronas do sistema nervioso central e son menos comúns noutros tecidos, pero tamén se expresan en niveis moi baixos nos astrocitos e oligodendrocitos do sistema nervioso central. As patoloxías e demencias do sistema nervioso como a enfermidade de Alzheimer poden orixinarse cando as proteínas tau son defectuosas e non poden estabilizar os microtúbulos apropiadamente.As proteínas tau son o produto do splicing alternativo do transcrito dun só xene que nos humanos se denomina MAPT (proteína asociada aos microtúbulos tau). Descubríronse en 1975 no laboratorio de Marc Kirschner na Universidade de Princeton.↑ Shin RW, Iwaki T, Kitamoto T, Tateishi J (May 1991). «Hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer's disease brain tissues». Lab. Invest. 64 (5): 693–702. PMID 1903170. ↑ Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A (June 1988). «Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau». Proc. Natl. Acad. Sci. U.S.A. 85 (11): 4051–5. PMC 280359. PMID 3131773. doi:10.1073/pnas.85.11.4051. ↑ Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA (October 1989). «Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease». Neuron 3 (4): 519–26. PMID 2484340. doi:10.1016/0896-6273(89)90210-9. ↑ Weingarten MD, Lockwood AH, Hwo SY, Kirschner MW (May 1975). «A protein factor essential for microtubule assembly». Proc. Natl. Acad. Sci. U.S.A. 72 (5): 1858–62. PMC 432646. PMID 1057175. doi:10.1073/pnas.72.5.1858.
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  • Goedert M, Crowther RA, Garner CC
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  • van Swieten J, Spillantini MG
  • Caffrey TM, Wade-Martins R
  • Delacourte A
  • Hirokawa N, Shiomura Y, Okabe S
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  • Fragmento da proteína MAPT unida ao dominio WWW da proteína PIN1
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  • October 1988
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  • Proteína asociada aos microtúbulos tau
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  • MAPT ; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; TAU
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  • Molecular characterization of microtubule-associated proteins tau and MAP2
  • Hyperphosphorylation of tau in PHF
  • Untangling tau-related dementia
  • Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease
  • [Recent advances in Alzheimer's disease]
  • CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer's disease
  • Tau gene mutations: dissecting the pathogenesis of FTDP-17
  • The tau gene locus and frontotemporal dementia
  • Phenotypic variation in frontotemporal dementia and parkinsonism linked to chromosome 17
  • Progressive supranuclear palsy--parkinsonian disorder with tau pathology
  • The role of tau in frontotemporal dementia and related tauopathies
  • Tau phosphorylation in Alzheimer's disease: pathogen or protector?
  • Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens
  • Dysregulation of tau phosphorylation is a hypothesized point of convergence in the pathogenesis of alzheimer's disease, frontotemporal dementia and schizophrenia with therapeutic implications
  • Tauopathies: classification and clinical update on neurodegenerative diseases associated with microtubule-associated protein tau
  • Untangling the tau gene association with neurodegenerative disorders
  • Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease
  • Hereditary frontotemporal dementia caused by Tau gene mutations
  • Functional MAPT haplotypes: bridging the gap between genotype and neuropathology
  • Tauopathies: recent insights into old diseases
  • Tau proteins: the molecular structure and mode of binding on microtubules
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  • As proteínas tau (ou proteínas τ) son proteínas asociadas aos microtúbulos que teñen a función de estabilizalos. Son abundantes nas neuronas do sistema nervioso central e son menos comúns noutros tecidos, pero tamén se expresan en niveis moi baixos nos astrocitos e oligodendrocitos do sistema nervioso central.
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